A ventricular pressure-clamping system for the study of mechano-electrical feedback.
- Author:
Hua WEI
1
;
Hai-Xia HUANG
;
Wei WANG
;
Zhi-Fei ZHANG
;
Xiao-Suo FU
;
Ping LIU
;
Wei-Zhen NIU
Author Information
1. Department of Physiology, Capital Medical University, Beijing 100069, China.
- Publication Type:Journal Article
- MeSH:
Action Potentials;
Animals;
Constriction;
Electrocardiography;
Feedback;
Heart;
physiology;
In Vitro Techniques;
Rabbits;
Ventricular Pressure
- From:
Acta Physiologica Sinica
2006;58(6):606-610
- CountryChina
- Language:English
-
Abstract:
It is necessary to control the mechanical stimuli precisely in the studies of cardiac mechano-electrical feedback (MEF). In the present study a ventricular pressure-clamping system has been developed, which can be applied to isolated-perfused rabbit hearts. Controlled by a computer, this system not only can make the left ventricle follow a command defining the same pressure wave as that during a beating cycle under physiological condition, but also deliver mechanical stimuli with a proper waveform to the ventricle at a particular time phase. This system integrates multiple functions, including perfusing, pacing, recording of electrocardiogram and monophasic action potentials, and clamping and measuring of ventricular pressures in isolated-perfused hearts. Thus, it is a distinct system for investigating the phenomena and mechanisms of cardiac MEF at organ level.
