Effect of volatile oil from nutmeg on liver microsomal cytochrome P450 in mice.
- Author:
Runying ZHAO
1
;
Wei WANG
;
Lini ZHAO
;
Zhao LI
;
Junping WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cytochrome P-450 Enzyme System; metabolism; Cytochromes b5; metabolism; Drugs, Chinese Herbal; pharmacology; Female; Gene Expression Regulation, Enzymologic; Male; Mice; Microsomes, Liver; drug effects; enzymology; Myristica fragrans; chemistry; Oils, Volatile; pharmacology; Plant Oils; pharmacology
- From: China Journal of Chinese Materia Medica 2009;34(4):447-449
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of the volatile oil from nutmeg on liver microsomal cytochrome P450 in mice.
METHODMice were administered the volatile oil from nutmeg at 0.4, 0.8 and 1.2 mg x g(-1), respectively, twice a day for 10 days. And then, the contents of liver microsomal cytochrome P450 (CYP), cytochrome b5 (Cytb5), MDA and GST in serum were examined by UV chromatography method.
RESULTThe contents of liver CYP, Cytb5 and GST in serum were increased significantly (P < 0.01) and the contents of MDA was reduced significantly (P < 0.01).
CONCLUSIONThe volatile oil from nutmeg showed induction effect on the hepatic microsomal CYP in mice.
