Study on pharmacokinetics and absolute bioavailability of sinomenine in beagle dogs.
- Author:
Wanyi CHEN
1
;
Yuanda ZHOU
;
Jiping KANG
;
Qiubo LI
;
Xiaoke FENG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biological Availability; Dogs; Drugs, Chinese Herbal; pharmacokinetics; Female; Injections, Intravenous; Male; Morphinans; pharmacokinetics; Tissue Distribution
- From: China Journal of Chinese Materia Medica 2009;34(4):468-471
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study pharmacokinetic parameters and absolute bioavailability for oral use of sinomenine tablet in beagle dogs.
METHODApplying to double cycle self crossover design, a single oral or intravenous dose of 10 mg x kg(-1) sinomenine was given to 10 beagle dogs. Drug concentrations in plasma were determined by HPLC. The pharmacokinetic parameters were calculated by 3P97 pharmacokinetic program.
RESULTThe concentration-time curves of oral administration fitted to one compartment model in the beagle dogs. The T(max), C(max), t1/2 and AUC(0-T) was (82.5 +/- 13.9) min, (0.15 +/- 0.027) mg x L(-1), (87.6 +/- 28.3) min and (28.43 +/- 3.48) mg x min x L(-1), respectively. The concentration -time curves of i.v. fitted to two compartment model in the beagle dogs. The t1/2beta and AUC(0-T) was (106.7 +/- 120.2) min and (93.32 +/- 82.08) mg x min x L(-1). The absolute bioavailability for oral use was (30.46 +/- 4.24)%.
CONCLUSIONThe absolute bioavailability of sinomenine is low, and the elimination of sinomenine tablet is fast.
