Studies of in vitro releasing properties on cyclovirobuxine D matrix-type patch.
- Author:
Yang YU
1
;
Liling ZHOU
;
Xiumei LI
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Cutaneous; Drugs, Chinese Herbal; administration & dosage; metabolism; pharmacokinetics; Models, Biological; Permeability; Skin; metabolism
- From: China Journal of Chinese Materia Medica 2009;34(7):825-828
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the drug releasing properties of Cyclovirobuxine D matrix-type patch.
METHODTo prepare Cyclovirobuxine D single-layered and double-layered patch was prepared and the study the drug releasing properties by in vitro releasing and in vitro skin permeation experiments was studied.
RESULTThe coefficient of first-order dynamical equation was good for single-layered patch, which means the releasing rate decreased with the amounts of drug decreasing. Nevertheless, Higuchi equation was good for double-layered patch, which means it belonged framing-type releasing system. In-vitro skin permeation experiment showed that zero-order dynamical equation was good for these two patches which indicated all of them abided by Ficks diffusion law.
CONCLUSIONThe structure of patch can change the drug releasing properties, the double-layered patch can obtain steady releasing and permeating rate because of storage layer releasing.
