Evaluation of nasal absorption for geniposide solution.
- Author:
Na WAN
1
;
Haiyan ZHANG
;
Runchun XU
;
Qin ZHENG
;
Ming YANG
Author Information
- Publication Type:Journal Article
- MeSH: Absorption; Administration, Intranasal; Animals; Diffusion; Drugs, Chinese Herbal; administration & dosage; metabolism; Iridoids; administration & dosage; metabolism; Kinetics; Linear Models; Male; Nose; metabolism; Perfusion; Rats; Sensitivity and Specificity; Solutions
- From: China Journal of Chinese Materia Medica 2009;34(7):839-842
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the regulation of geniposide nasal absorption.
METHODWe used rat in situ nasal recirculation method as experimental model. The effects of perfusion volume, flow rate, perfusion concentration on nasal absorption of geniposide were studied.
RESULTGeniposide was stable in rats nasal lavage solution. At the perfusion volume 5 mL and flow rate 2.5 mL x min(-1), the absorption rate of geniposide remains constant in a dose-independent manner.
CONCLUSIONThe mechanism of geniposide nasal absorption is passive diffusion following first order kinetics and the absorption rate constant is 4.20 x 10(-3).
