Effect of borneol/mentholum eutectic mixture on nasal-brain delivery of neurotoxin loaded nanoparticles.
- Author:
Guobao CHAI
1
;
Yuefang PAN
;
Fanzhu LI
Author Information
- Publication Type:Journal Article
- MeSH: Absorption; drug effects; Animals; Bornanes; chemistry; pharmacology; Brain; metabolism; Drug Carriers; pharmacokinetics; Male; Menthol; chemistry; pharmacology; Microdialysis; Nanoparticles; Nasal Cavity; metabolism; Neurotoxins; administration & dosage; pharmacokinetics; Rats
- From: China Journal of Chinese Materia Medica 2009;34(6):698-701
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the absorption enhancen effect of borneol/mentholum eutectic mixture (BO/ME) on nasal-brain delivery of neurotoxin loaded nanoparticles.
METHODUsing microdialysis sampling technique in awake freely-moving rats, the counter per minute (cpm) of dialysates in right PAG of NT-loaded nanoparticles with the BO/ME (BO/ME-NT-NP), radiolabeled with sodium 125I-Iodide, were measured in a gamma-counter for radioactivity. After converting cpm into corresponding concentrations of NT byin vivorecovery of microdialysis probes, the pharmacokinetic parameters were calculated.
RESULTThe BO/ME-NT-NP could be absorbed into the brain, much better to NT-NP and the nanoparticles with borneol or menthdlum only, and the pharmacokinetics accorded with the two-compartment model. The parameters tmax, cmax, AUC, t 1/2(beta) were 0.68 h, 27.32 ng x mL(-1), 132.68 ng x h x mL(-1), 3.1076 h.
CONCLUSIONWith adding BO/ME as absorption enhancer, NT could be significantly increased in the brain with the help of nanopartilces as carriers, and the time to maximal concentration was short, the elimination process was prolonged.
