Study on the expression of C-erbB-2 gene in coal miners with pneumoconiosis complicated by pulmonary cancer.
- Author:
Jun-hua PENG
1
;
Chuan-dan ZHU
;
Yong-lai SHEN
;
Wen-shou XU
;
Tai-ke ZHANG
;
Hong-mei HOU
;
Jing SUN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; China; Coal Mining; Gene Expression; Genes, erbB-2; Genotype; Humans; Lung Neoplasms; complications; genetics; pathology; Lymphatic Metastasis; Male; Middle Aged; Pneumoconiosis; complications; genetics; pathology; Prognosis; Receptor, ErbB-2; genetics; metabolism; Survival Analysis
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2003;21(3):169-171
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the difference in the expressions of C-erbB-2 gene between the coal miners with pneumoconiosis complicated by pulmonary cancer and the controls with single pulmonary cancer, and its relation to clinical pathology.
METHODMeasuring the expressions of C-erbB-2 in 32 cases of pneumoconiosis complicated by pulmonary cancer and those in 30 cases of pulmonary cancer by means of immunohistochemistry.
RESULTSThe positive expression rate in 32 cases of pneumoconiosis complicated by pulmonary cancer was 53.13% whereas that in 30 cases of single pulmonary cancer was 26.67% (P < 0.05); the positive expressions of C-erbB-2 in patients with lymph node metastasis (70.59% in pneumoconiosis group, 50.00% in controls) were significantly different from those without lymph node metastasis (33.33% in pneumoconiosis group, 11.11% in controls) (P < 0.05). The prognosis on patients with positive expressions of C-erbB-2 was poor, and was not related to pathologic category.
CONCLUSIONC-erbB-2 gene may be an important regulating gene in the coal miners with pneumoconiosis complicated by pulmonary cancer, and as a reference index to determine lymph node metastasis and prognosis.
