A study on biomarkers of styrene.
- Author:
Hua SHAO
1
;
Xiao-yun WANG
;
Hu CHENG
;
Yi-kang SHI
;
Meng-ping ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Acetylcysteine; urine; Adult; Biomarkers; Chromatography, High Pressure Liquid; Environmental Monitoring; Glyoxylates; urine; Humans; Male; Mandelic Acids; urine; Regression Analysis; Styrene; metabolism
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2003;21(2):93-95
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the biomarkers of styrene and to provide theoretical basis for bio-monitoring of styrene.
METHODSUrinary mandalic acid (MA), phenylglyoxalic acid (PGA) and mercapturic acid (MUA) of styrene were examined by high performance liquid chromatography (HPLC).
RESULTSThe correlation regression equations between exposure dose and MA, PGA and MUA level in morning urinary samples were: ŷ = 2.58x + 70.82; ŷ = 1.66x + 37.42; ŷ = 0.05x + 0.55 respectively. The correlation regression equations between exposure dose and MA, PGA and MUA level in post-shift urinary samples were: ŷ = 1.85x + 89.02; ŷ = 1.33x + 4.32; ŷ = 0.04x + 0.68 respectively. All showed close dose-response relationship.
CONCLUSIONSThe level of MA, PGA and MUA in morning or post-shift urinary samples may be used as bio-monitoring indexes of styrene.
