Study on mitochondrial DNA damage in peripheral blood nucleate cells of the workers exposed to acrylonitrile.
- Author:
Sheng DING
1
;
Lai-ji MA
;
Wei FAN
;
Rui-juan ZHU
;
Qi YING
;
Yuan-ling ZHOU
;
Fu-sheng JIN
Author Information
- Publication Type:Journal Article
- MeSH: Acrylonitrile; toxicity; Adolescent; Aged; Aged, 80 and over; Aging; drug effects; Blood Cells; drug effects; ultrastructure; DNA Damage; DNA, Mitochondrial; drug effects; Humans; Occupational Exposure
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2003;21(2):99-101
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the potential aging effect on workers exposed to acrylonitrile (ACN).
METHODSThe deletion rates of mitochondrial DNA (mtDNA) in peripheral blood nucleate cells of 47 exposed workers and 47 non-exposed workers (as control), as well as 12 old people and 12 young people were measured with polymerase chain reaction (PCR).
RESULTSThe positive rates of mtDNA deletion in peripheral blood nucleate cells were 17.02% in the workers exposed to ACN and 25.00% in group of old people. However, the mtDNA deletion was not detected in the control group and young people.
CONCLUSIONSACN could induce mtDNA deletion in peripheral blood nucleate cells of the exposed workers. There may be a potential molecular effect of occupational ACN exposure on workers' aging.
