Role of LNK gene mutation in pathogenesis of myeloproliferative neoplasms-review.
10.7534/j.issn.1009-2137.2013.05.045
- Author:
Yan CHEN
1
,
2
;
Xue-Qiang WU
;
Chun-Sheng HAN
;
Ping ZHU
;
Jun-Yan WEI
Author Information
1. Institute of Hematology & Oncology, Beijing Aerospace General Hospital, Beijing 100076, China
2. The Second Department of Pediatrics, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou Province, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Janus Kinases;
metabolism;
Mutation;
Myeloproliferative Disorders;
genetics;
Proteins;
genetics;
STAT Transcription Factors;
metabolism;
Signal Transduction
- From:
Journal of Experimental Hematology
2013;21(5):1309-1312
- CountryChina
- Language:Chinese
-
Abstract:
Myeloproliferative neoplasms ( MPN ) is a class of clonal hematopoietic stem cell disease. Studies found that the JAK-STAT signaling pathway is closely related to the pathogenesis of MPN. The lymphocyte-specific adaptor protein (LNK) gene negatively regulates Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling and may play an important role in the pathogenesis of MPN. Especially in JAK2 mutation-negative MPN, LNK gene specific mutations may be the key to cause MPN subtypes. Certain single nucleotide polymorphism of LNK gene regulation of hematopoietic cells in different directions may also be important influence factors of MPN performance for different subtypes. LNK gene functional changes lead to abnormal activation of the JAK-STAT signaling pathway, and may be a new mechanism of MPN. In this review, the role of LNK gene in MPN pathogenesis is briefly summarized.
