Recent advances of studies on role of mTOR signaling in aging of hematopoietic and other organ systems-review.
10.7534/j.issn.1009-2137.2013.05.046
- Author:
Chun-Lan HUA
1
;
Tao CHENG
;
Wei-Ping YUAN
Author Information
1. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
- Publication Type:Journal Article
- MeSH:
Aging;
Hematopoietic System;
metabolism;
Humans;
Signal Transduction;
TOR Serine-Threonine Kinases;
metabolism
- From:
Journal of Experimental Hematology
2013;21(5):1313-1317
- CountryChina
- Language:Chinese
-
Abstract:
Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase, which plays an essential role in cell growth, proliferation and survival. mTOR regulates the transcription of mRNA, synthesis of ribosome and gene expression for metabolism. By forming mTOR complex, it regulates cellular activities by phosphorylating its downstream proteins, such as S6 protein kinase and 4E-BP1. In recent years, the role of mTORC1 in regulating aging is gradually recognized. Studies of physiological function and the regulatory mechanisms of mTOR signaling can not only help to better understand the aging mechanism for cells or organs, but also provide insights as to finding potential new drug targets for aging related diseases. This review focuses on recent advances of mTOR and aging related diseases in hematopoietic and other organ systems.
