Progress of microRNA in diagnosis and prognosis of diffuse large B cell lymphoma-review.
10.7534/j.issn.1009-2137.2013.05.053
- Author:
Xin-Nian YU
1
;
Bao-An CHEN
Author Information
1. Department of Hematology (key Discipline of Jiansu Province), Zhongda Hospital Affiliated to Southeast University Medical college, Nangjing 210009,Jiangsu province, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Lymphoma, Large B-Cell, Diffuse;
diagnosis;
MicroRNAs;
Prognosis
- From:
Journal of Experimental Hematology
2013;21(5):1351-1355
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA) is a class of naturally occurring short non-coding small molecular RNA with 19-25 nucleotide. MiRNA can regulate gene expression through incompletely binding to complementary sequences in the 3'UTR of target mRNA. MiRNA plays key regulatory role in a diverse rang of pathways, including cell proliferation, differentiation, apoptosis, stem cell development. Many studies have shown that many miRNA have a special role of gene regulation in cancer development and have been used as therapeutic targets and diagnostic markers of cancer. This review focuses on recent advances of studies on miRNA involved in tumorigenesis, and in classification, diagnosis, therapy and prognosis of DLBCL.
