Research progress on B lymphocyte-induced maturation protein 1 and its relationship with the development of lymphoma.
10.7534/j.issn.1009-2137.2013.06.048
- Author:
Zhi-Yin LIU
1
;
Jun-Min LI
2
Author Information
1. Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
2. Department of Hematology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. E-mail: lijunmin@medmail.com.cn.
- Publication Type:Journal Article
- MeSH:
B-Cell Maturation Antigen;
genetics;
B-Lymphocytes;
Cell Differentiation;
Humans;
Lymphoma, Large B-Cell, Diffuse;
Positive Regulatory Domain I-Binding Factor 1;
Repressor Proteins;
metabolism;
Transcription Factors
- From:
Journal of Experimental Hematology
2013;21(6):1623-1626
- CountryChina
- Language:Chinese
-
Abstract:
Many studies show that as a transcription factor, B lymphocyte-induced maturation protein 1 (Blimp 1) is the master regulator of plasma-cell differentiation. The abnormality of Blimp 1 plays an important part in the genesis and development of lymphoma. This review introduces and summarizes Blimp 1's protein structure and functions, its role in B cell differentiation, its main target genes and the mechanism of its transcriptional repressor activity. Besides, the relationship between Blimp 1 gene mutation or Blimp 1 protein expression reduction and the development of DLBCL is preliminary summaried.
