Clinical characteristics and therapeutic efficacy of normal karyotype AML patients with CEBPA mutation.
10.7534/j.issn.1009-2137.2014.01.004
- Author:
Ya-Zhe DU
1
;
Long SU
1
;
Wei LI
1
;
Ping YU
1
;
Ye-Hui TAN
1
;
Hai LIN
1
;
Su-Jun GAO
2
Author Information
1. Cancer Center, the First Norman Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China.
2. Cancer Center, the First Norman Bethune Hospital, Jilin University, Changchun 130021, Jilin Province, China. E-mail:gaosujunjdyy@163.com.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
CCAAT-Enhancer-Binding Proteins;
genetics;
Child;
Female;
Humans;
Karyotype;
Karyotyping;
Leukemia, Myeloid, Acute;
diagnosis;
genetics;
therapy;
Male;
Middle Aged;
Mutation;
Prognosis;
Retrospective Studies;
Treatment Outcome;
Young Adult
- From:
Journal of Experimental Hematology
2014;22(1):16-19
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to explore the clinical characteristics and therapeutic efficacy of normal karyotype AML patients with CEBPA mutations. Fifty-five de novo AML patients with normal karyotype were retrospectively analyzed with regard to frequency of CEBPA mutation, clinical characteristics and therapeutic response. The results showed that CEBPA mutation was detected in 20 patients (36.4%), among them 17 cases displayed double mutations, three cases were with single mutation. The clinical characteristics of patients with CEBPA mutation displayed as follows: 75% of AML patients with CEBPA mutation were AML-M1 and AML-M2, the hemoglobin level at newly diagnosis was higher and the platelet count at newly diagnosis time was lower than those of AML patients without CEBPA mutation [(98.30 ± 20.33) g/L vs (81.69 ± 23.74) g/L (P < 0.05); and (33.30 ± 38.27) ×10(9)/L vs (64.79 ± 61.60) ×10(9)/L (P < 0.05)]. The leukemic cells highly expressed CD7 and CD34. The therapeutic efficacy of 1 cycle for AML patients with CEBPA mutation was satisfactory (72.2%), was higher than that of patients without CEBPA mutation(68.6%), but there was no statistical significance (P > 0.05). It is concluded that AML with CEBPA mutation is more observed in AML-M1 and AML-M2, and accompanies by high level of hemoglobin and lower platelet count, expression of CD7 and CD34. Early-term therapeutic efficacy is satisfactory. The frequency of CEBPA mutation may be higher in Chinese patients with AML compared with that reported in Western world.
