Study on antidepressant components of sucrose ester from Polygala tenuifolia.
- Author:
Hai-Hua TU
1
;
Ping LIU
;
Liang MU
;
Hong-Bo LIAO
;
Ting-Ting XIE
;
Li-Hua MA
;
Yao-Ming LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antidepressive Agents; chemistry; isolation & purification; pharmacology; Esters; chemistry; isolation & purification; pharmacology; Mice; PC12 Cells; Plant Roots; chemistry; Polygala; chemistry; Rats; Sucrose; chemistry
- From: China Journal of Chinese Materia Medica 2008;33(11):1278-1280
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the antidepressant components of Polygala tenuifolia.
METHODThe chromatographic method was used to isolate and purify the chemical constituents, their structures were identified by spectral analysis, MTT method was applied to investigate their cytotoxic activities.
RESULTNine compounds were isolated from the roots of P. tenuifolia. Their structures were identified as sibiricose A, (1), sibiricose A5 (2), tenuifoliside A (3) and 3', 6-disinapoyl sucrose (4), sibiricose A6 (5), 3, 4, 5-trimethoxycinnamate (6), polygalaxanthone III (7), tenuifolioses A (8), tenuifolioses H (9) and some compounds' activities to PC12 were observed.
CONCLUSIONCompound 1 was isolated from this plant for the first time. Compounds 2,3 could protect PC12 cells damage induced by P. tenuifolia.
