Evaluation of targeting property for Kuikang colon targeted pellets.
- Author:
Ya-Jun ZHANG
1
;
Jiang-Ying LI
;
Lian-Ying XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Colon; metabolism; Drug Delivery Systems; Drug Implants; Drugs, Chinese Herbal; administration & dosage; metabolism; Flavanones; metabolism; Flavonoids; metabolism; Ileum; metabolism; Logistic Models; Rats; Rats, Wistar
- From: China Journal of Chinese Materia Medica 2008;33(13):1556-1604
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate colon targeting characteristic of Kuikang colon targeted pellets (KCP) with determination of residual baicalin and baicalein concentration in gastrointestinal tract (GIT).
METHODThe baicalin and baicalein were assayed by HPLC. The recovery differences of the drug between KCP and conventional pellets from GIT were investigated, three and six hours after administration.
RESULTThe baicalin recovery of KCP (70%) from rat GIT was higher than that of CP (about 20%). Most of KCP were intact at 3 h after oral administration, and distributed in lower ileum. It indicated that release site of KCP was in lower ileum and colon. Six hours later, a small amount of baicalin was recovered in intestime, which showed that the release of baicalin from KCP was complete.
CONCLUSIONThe determination of residual baicalin in rat GIT was feasibility for evaluating KCP. The result confirmed KCP of colon targeting property.
