A new cycloartane triterpene saponin from rhizome of Actaea asiatica.

Author: Bin LU ¹ ; Yun-Shuang FAN ; Hong-Quan DUAN
Author Information

1. School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin 300070, China.
Publication Type:Journal Article
MeSH: Actaea; chemistry; Animals; Cell Line, Tumor; Cell Proliferation; drug effects; Humans; Mice; Plant Structures; chemistry; Saponins; isolation & purification; pharmacology
From: China Journal of Chinese Materia Medica 2008;33(13):1558-1561
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo isolate and elucidate the chemical constituents with the cytotoxicity activity from the rhizome of Actaea asiatica.
METHODThe chemical constituents were isolated by repeated column chromatography (Toyopearl HW40C and preparative HPLC) and the structure of compound 1 was elucidated by spectral data analysis.
RESULTA cycloartane triterpene saponin com- pound was isolated and identified to be (23R)-16beta, 23: 23alpha, 26: 24alpha: 25-triepoxy-9, 19-cyclolanost-7-en-3beta-O-beta-D-xylopyranoside.
CONCLUSIONCompound 1 was a new compound and named (23R)-26-deoxycimicifugoside. The IC50 values of compound 1 for cell growth inhibition of Hela and L929 cell lines were 72.24 and 55.97 mg x L(-1), respectively.