Effect of weiganli on level of FL in bone marrow and serum of myelosuppressed anemic mice.
- Author:
Yong-Feng CHEN
1
;
Bi-De ZHU
;
Li ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Anemia; blood; immunology; metabolism; pathology; Animals; Bone Marrow; drug effects; metabolism; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; pharmacology; Male; Membrane Proteins; blood; metabolism; Mice; Mice, Inbred BALB C; Myeloid Cells
- From: China Journal of Chinese Materia Medica 2008;33(13):1587-1590
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Weiganli on the level of FL in bone marrow and serum of myelosuppressed anemic mice, and to explore it's function on hematopoietic regulation.
METHODModels of myelosuppressed anemic mice were induced by radiation and chemotherapeutic drug, and the mice were randomly divided into normal group, myelosuppressed anemic group, and Weiganli group (high dose 100 g x L(-1), medium dose 50 g x L(-1), low dose 25 g x L(-1)). Effect of Weiganli on the number of the peripheral blood cells and bone marrow nucleated cells (BMC) were evaluated. Effect of Weiganli on the level of FL (Flt3 ligand) was investigated by ELISA technique.
RESULTHigh dose of Weiganli could significantly increase granulocytes, erythrocytes, Hb and BMC, while both the medium dose and the low dose had more significant action in increase of platelet. The level of FL in bone marrow and serum were lower in Weiganli group than that in myelosuppressed anemic group, especially in high and medium dose group.
CONCLUSIONThe myelosuppresion of mice which induced by radiation and chemotherapeutic drug could be significantly relieved by Weiganli.
