Effect of supplemented Taoren Chengqi decoction on NIT-1, a pancreatic beta-cell from a transgenic NOD/Lt mouse.
- Author:
Fan-Min MENG
1
;
Yu-Ying ZHAO
;
Hong WANG
;
Yan-Song ZHANG
;
Qing-Yan LI
;
Li-Ying LI
;
Qing-Ying ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Line; Cell Proliferation; drug effects; Drugs, Chinese Herbal; administration & dosage; pharmacology; Insulin; secretion; Insulin-Secreting Cells; cytology; drug effects; metabolism; secretion; Male; Mice; Mice, Inbred NOD; Mice, Transgenic; Rats
- From: China Journal of Chinese Materia Medica 2008;33(13):1602-1604
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of Supplemented Taoren Chengqi decoction (STCD) on the secretion of insulin and proliferation of NIT-1.
METHODThe effect of STCD and the serum of rat after orally administrating of STCD on the secretion of insulin and proliferation of NIT-1 were studied. The proliferation of NIT-1 was measured by 3H-TdR incorporation and cell counting methods, while the secretion of insulin was measured from the cultured medium by the ultra sensitive rat insulin ELISIA kit.
RESULTBoth the STCD and the serum of rat after orally administrating of STCD significantly could increased the secretion of insulin and proliferation of NIT-1.
CONCLUSIONThe treatment of the diabetic patients by STCD might be through with its improvement of secretion of insulin and proliferation on pancreatic beta-cell.
