Study on absorption kinetics of astragaloside IV in rats intestines.
- Author:
Huai-Peng HUANG
1
;
Cai-Xia LIU
;
Yan-Ling LI
;
Guo-Ling GAO
Author Information
- Publication Type:Journal Article
- MeSH: ATP-Binding Cassette, Sub-Family B, Member 1; antagonists & inhibitors; Animals; Chromatography, High Pressure Liquid; Intestinal Absorption; drug effects; Intestines; metabolism; Kinetics; Male; Perfusion; Rats; Rats, Wistar; Saponins; metabolism; pharmacokinetics; Triterpenes; metabolism; pharmacokinetics; Verapamil; pharmacology
- From: China Journal of Chinese Materia Medica 2008;33(13):1609-1611
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the mechanisms of intestine absorption of astragaloside IV in rat.
METHODThe K(a) and P(app) of astragaloside IV was investigated using single-pass intestinal perfusion technique in rats. HPLC was used to determine the concentration of astragaloside IV. The effect of absorption site, drug concentration and the inhibitors of P-glycoproteon on the absorption had been studied.
RESULTBy the testing of the statistics, the K(a) and the P(app) values of the duodenum, jejunum, ileum, colonic had significant differences (P < 0.05). The concentration from 20-80 mg x L(-1) had no distinctive effect on the K(a) and P(app) of small intestine. The inhibitors of P-glycoproteon had no distinctive effect on the absorption of small intestine.
CONCLUSIONAstragaloside IV is absorbed by typical passive diffusion mechanism.
