Drug release of sustained-released tablets of total Puerariae flavones.

Author: Feng SHI ¹ ; Chun-yan ZHU
Author Information

1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100094, China.
Publication Type:Journal Article
MeSH: Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drugs, Chinese Herbal; administration & dosage; chemistry; metabolism; Flavones; chemistry; metabolism; Pueraria; chemistry; Reproducibility of Results; Tablets
From: China Journal of Chinese Materia Medica 2008;33(12):1396-1398
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study drug release of sustained-released tablets of total puerariae flavones and investigate the evaluating method of sustained released preparations Chinese material medica sustained-released preparation.
METHODRotating basket method and HPLC were employed to assess the characteristics of multi-component.
RESULTUnder the selected chromatographic conditions, good HPLC fingerprint of the release of sustained-released tablets of total puerariae flavones were obtained. Through the determination of 8 time-point samples,the release of sustained-released tablet of total puerariae flavones had a well-balanced release behavior.
CONCLUSIONThe HPLC-UV fingerprint method was simple and reproducible, quality of tablets of total puerariae flavones can be controlled effectively by the method. The method could be applied to evaluate the release of sustained-released tablets of total puerariae flavones.