Preliminary study of effects and mechanisms of qingpeng paste on type II collagen-induced arthritis in rats.
- Author:
Chao-yong HE
1
;
Nan LI
;
Jie MA
;
Li-hua CHEN
;
Wei-dong LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Arthritis, Rheumatoid; chemically induced; drug therapy; metabolism; pathology; Collagen Type II; adverse effects; Drugs, Chinese Herbal; pharmacology; therapeutic use; Female; Gene Expression Regulation; drug effects; Interleukin-1alpha; metabolism; Interleukin-1beta; metabolism; Rats; Rats, Wistar; Synovial Membrane; drug effects; metabolism; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2008;33(12):1455-1458
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of Qingpeng paste (QP) on collagen-induced arthritis (CIA) in rats.
METHODCIA was established in female Wistar rats with injection of type II bovine collagen at the base of the tail of animals. CIA rats were treated daily with external administration of different doses of QP or voltaren beginning on the day after the onset of arthritis (day 1) until day 20. Paw swelling rate and the serum levels of IL-1 beta were determined. Moreover, the expression of TNF-alpha and IL-alpha and histopathological changes in the arthritic joints were also observed.
RESULTQP markedly suppressed the paw swelling rate of arthritic rat, reduced the expression of TNF-alpha and IL-alpha in synovial membrane. Histopathological changes in the arthritic joints were also significantly ameliorated in the QP-treated versus vehicle-treated rats. However, the elevated serum levels of IL-1 beta in arthritic rats were not influenced by QP.
CONCLUSIONThe present findings demonstrate the protective property of QP on collagen-induced arthritis, mechanisms underlying it may be related to reduce the expression of IL-1alpha and TNF-alpha in synovial membrane.
