Studies on pharmacokinetics of artemether patch in mice.
- Author:
Hua-sheng YANG
1
;
Zu-guang YE
;
Bing-wen LIANG
;
Nai-jie WANG
;
Cheng HE
;
Jin-sheng LI
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Cutaneous; Administration, Oral; Animals; Artemisinins; administration & dosage; blood; metabolism; pharmacokinetics; Calibration; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; administration & dosage; metabolism; pharmacokinetics; Male; Mice; Mice, Inbred ICR; Sensitivity and Specificity; Tandem Mass Spectrometry
- From: China Journal of Chinese Materia Medica 2008;33(12):1459-1462
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a HPLC-MS-MS determination method of artemether (ARM) and active derivatives DHA, and compare the pharmacokinetic parameters of ARM after transdermal and oral administration.
METHODThe mice were divided two groups (transdermal and oral) by parallel design. ARM and active derivatives DHA in plasma of mice at different sampling time were determined. The pharmacokinetic parameters were calculated by DAS 2.0 and by statistic analysis.
RESULTcompare oral administration, the pharmacokinetic parameters of ARM after transdermal, Cmax Tmax , AUC(0-t) MRT, had significant difference (P < 0.05).
CONCLUSIONThe artemether patch has long-releasing property.
