Protective effect of injection of Danhong against acute myocardial ischemia in dogs.
- Author:
Yan GUO
1
;
Liu-yi DONG
;
Zhi-wu CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Creatine Kinase; blood; Dogs; Drugs, Chinese Herbal; administration & dosage; pharmacology; Injections; L-Lactate Dehydrogenase; blood; Myocardial Infarction; blood; complications; pathology; Myocardial Ischemia; blood; complications; drug therapy; prevention & control
- From: China Journal of Chinese Materia Medica 2008;33(12):1463-1465
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protective effects of injection of Danhong against acute myocardial ischemia in dogs.
METHODThe myocardial ischemia model were established by ligation of coronary artery in dogs. The degree of myocardial ischemia and the myocardial infarction size were observed before and after giving injection of Danhong. The serum creatine phosphokinase (CK) and lactate dehydrogenase (LDH) activities were also determined.
RESULTInjection of Danhong (1, 2, 4 g x kg(-1)) could significantly decreased the damage degree of myocardial ischemia, redused myocardial infarction size and also reduced the serum LDH and CK activities.
CONCLUSIONInjection of Danhong had protective action on myocardial ischemia.
