Effects of Shujing Ketong soft capsules on uterine activity of animals.
- Author:
Yan XIE
1
;
Zhen-yu XUAN
;
Li YU
;
Jing GUO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Capsules; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; pharmacology; therapeutic use; Dysmenorrhea; drug therapy; physiopathology; Female; In Vitro Techniques; Muscle, Smooth; drug effects; physiology; Oxytocin; adverse effects; Rats; Rats, Wistar; Time Factors; Uterine Contraction; drug effects; Uterus; drug effects; physiology
- From: China Journal of Chinese Materia Medica 2008;33(12):1466-1469
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe effects of Shujing Ketong soft capsules (SJKTSC) on activities of the uterine of the rat in vitro and in vivo.
METHODThe isolated rat uterine were mounted in the improved Genell solution with a final content of 0. 96, 1.92, 3.84 microg x g(-1) of SJKTSC at 37 degrees C; and 9. 6, 19. 2, 38.4 mg x kg(-1) of SJKTSC and 2 g x kg(-1) of Tongjingbao granules were given to the rat through the duodenum respectively. Their effects on frequency, amplitude and activity of contraction of rat uterus in vitro and in vivo were investigated.
RESULTSJKTSC could significantly inhibit the frequency, amplitude and activity of contraction of the normal rat uterus in vitro and decrease the oxytocin-induced increase of contraction of the rat uterus in vitro; lowered the frequency, amplitude and activity of the oxytocin-induced contraction of the rat uterus in vivo and inhibit the oxytocin-induced the strengthening of contraction of the rat uterus in vivo.
CONCLUSIONShujing Ketong soft capsules maybe used for treatment of dysmenorrhea induced by spasm of uterine smooth muscle.
