Formulation optimization of panax notoginsenoside orally fast disintegration tablets.
- Author:
Zhi WANG
1
;
Li WEI
;
Ting CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Cellulose; chemistry; Chemistry, Pharmaceutical; methods; Drugs, Chinese Herbal; chemistry; Ginsenosides; chemistry; Lactose; chemistry; Mannitol; chemistry; Tablets; chemistry; Tensile Strength
- From: China Journal of Chinese Materia Medica 2008;33(14):1676-1680
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the formulation of panax notoginsenoside orally fast disintegrating tablets.
METHODMannitol, microcrystalline cellulose (PH 102) and lactose 80 were used as diluent. A polynomial regression algorithm was used to evaluate the relationship between the controlling factor, compacting pressure and diluent ratio, and disintegration time, tensile strength of tablets. Optimum formulation and process parameters could be determined by contrast the contour plot of tensile strength to that of disintegration time.
RESULTThe disintegration time and tensile strength of panax notoginsenoside oral disintegrating tablets were good, and the taste was satisfactory.
CONCLUSIONPanax notoginsenoside oral disintegrating tablets achieve the goal of design and this method can be fairly used in formulation screening.
