Influence of cytokine gene polymorphism on renal transplantation.
- Author:
Ye TIAN
1
;
Weiran MA
;
Yuhai ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Cytokines; genetics; Female; Gene Expression; Gene Frequency; Graft Rejection; epidemiology; genetics; Humans; Interleukin-10; genetics; Kidney Transplantation; physiology; Male; Middle Aged; Polymorphism, Genetic; Tumor Necrosis Factor-alpha; genetics
- From: Chinese Journal of Surgery 2002;40(4):256-258
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of cytokine gene polymorphism on the incidence of acute rejection in renal transplantation.
METHODSThe cytokine genotypes of TNF-alpha, TGF-beta(1), IL-10 and IL-6 in 24 normal people and 115 consecutive renal transplant recipients were determined by PCR-SSP using sequence-specific oligonucleotide primer. The cytokine genotypes were then correlated with the incidence of acute rejection in renal transplantation.
RESULTSThe frequency of TNF-alpha and IL-10 low producer genotype in the 115 kidney recipients and control group was 88.7%, 80% and 87.5%, 75% respectively, and the frequency of TGF-beta(1) and IL-6 high producer genotype was 79.1%, 100% and 66.7%, 100% respectively. The incidence of acute rejection was higher in the recipients with TNF-(high producer or IL-10 intermediate high producer genotype than in the recipients with low producer genotype [53.8%, 43.5% vs 18.6% (chi(2) = 8.17), 17.4% (chi(2) = 7.16), P < 0.01, respectively].
CONCLUSIONThis study demonstrated that TNF-alpha and IL-10 gene polymorphism has significant influence on the incidence of acute rejection in renal transplantation.
