Expression and clinical significance of c-kit oncogene in gastrointestinal stromal tumors.
- Author:
Xiaohong LIU
1
;
Dalie MA
;
Lili WU
;
Chenguang BAI
;
Hongjie HU
Author Information
- Publication Type:Journal Article
- MeSH: Biomarkers, Tumor; biosynthesis; genetics; Diagnosis, Differential; Gastrointestinal Neoplasms; diagnosis; metabolism; Humans; Immunohistochemistry; Mutation; Prognosis; Proto-Oncogene Proteins c-kit; biosynthesis; genetics
- From: Chinese Journal of Surgery 2002;40(4):277-279
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinicopathological and prognostic significance of the c-kit protein in gastrointestinal stromal tumor (GIST).
METHODSParaffin embedded materials from 53 benign GISTs, 13 potentially malignant and 55 malignant cases were analysed for c-kit expression by immunohistochemical method, while using leiomyomas and schwannomas as controls. Positive signals were shown in cytoplasma and cell membrane.
RESULTSOf 122 GISTs, 118 (97%) were positive for c-kit. Localization of positive signals was accurate. The rate of c-kit protein in benign, potentially malignant and malignant cases was 98% (53/54), 93% (12/13), 96% (53/55) respectively. Compared with benign GIST, the positivity of c-kit in metastasis or recurrent cases decreased, but c-kit protein expression rate was not significantly different between the three patterns of GIST (chi(2) = 1.167, P > 0.05). Leiomyomas and schwannomas were typically c-kit negative.
CONCLUSIONAs a sensitive and specific marker of GIST, c-kit seems to be a useful antibody in the diagnosis and differential diagnosis of GIST, but it may not be used as a prognostic index.
