Long-term results of preoperative regional intraarterial chemotherapy against colorectal cancer.
- Author:
Jin GU
1
;
Yifan PENG
;
Zhaolai MA
;
Xisheng LENG
;
Yi WANG
;
Guangwei XU
Author Information
- Publication Type:Journal Article
- MeSH: Antineoplastic Agents; administration & dosage; Colorectal Neoplasms; drug therapy; mortality; pathology; Female; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Prognosis
- From: Chinese Journal of Surgery 2002;40(6):404-406
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVESTo summarize the clinical experience of preoperative intraarterial chemotherapy (PRAC) and evaluate the long-term results of multimodality against colorectal cancer.
METHODSSeldinger procedure was used to intubate the tube to the artery branch which supplied blood to the tumor. The tumor was imaged to make sure the diagnosis and irrigate the chemotherapeutic drugs. Ten days after PRAC, the patients received radical operation and 6 chemotherapeutic courses with FCF regimen. Concurrent patients receiving surgical treatment yet no PRAC therapy were chosen as controls.
RESULTSOne-year survival rate was 93.05% in the PRAC group and 80.78% in the controls (P = 0.023). COX multivariate analysis was used to analyse the prognostic factors. Dukes'staging and the PRAC prescription or not were found to be independent prognostic factors of colorectal cancer patients. Patients in the PRAC group survived longer than those in the control group.
CONCLUSIONPRAC can improve the survival of colorectal cancer patients.
