Pathogenesis of hilar cholangiocarcinoma and infection of hepatitis virus.
- Author:
Xiaofang LIU
1
;
Shengquan ZOU
;
Fazu QIU
Author Information
1. Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Liu634@263.net
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Animals;
Bile Duct Neoplasms;
etiology;
Bile Ducts, Intrahepatic;
Cholangiocarcinoma;
etiology;
Female;
Hepatitis B;
complications;
Hepatitis C;
complications;
Humans;
Male;
Mice;
Middle Aged;
Trans-Activators;
analysis;
Viral Core Proteins;
analysis
- From:
Chinese Journal of Surgery
2002;40(6):420-422
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the correlation between hepatic hilar cholangiocarcinoma and the infection of HB (C)V. METHODS Combined with clinical data, immunohistochemistry was used to detect HBXAg antigen and HCV-C protein in 68 formalin-fixed and paraffin-embedded samples of hilar cholangiocarcinoma. RESULTS Six cases(8.8%) were positive to HBXAg antigen and 24 cases (35.0%) to HCV-C protein respectively. One case was positive to both HBXAg antigen and HCV-C protein. There were statistical differences in differentiation and invasion, lymph node metastasis, treatment between hilar cholangiocarcinomas infected HB(C)V and those non-infected. CONCLUSIONS HBXAg antigen and HCV-C protein may play an important role in the pathogenesis of hilar cholangiocarcinoma. Hilar cholangiocarcinoma infected HB(C)V may have a high malignancy and more poor prognosis.
