ATP-sensitive potassium channels: novel potential roles in Parkinson's disease.
- Author:
Jie ZENG
1
;
Gang WANG
;
Sheng-Di CHEN
Author Information
1. Department of Neurology and Neuroscience Institute, Ruijin Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
- Publication Type:Journal Article
- MeSH:
Humans;
KATP Channels;
drug effects;
physiology;
Mitochondria;
metabolism;
Parkinson Disease;
metabolism;
therapy
- From:Neuroscience Bulletin
2007;23(6):370-376
- CountryChina
- Language:English
-
Abstract:
The ATP-sensitive potassium (K(ATP)) channels which extensively distribute in diverse tissues (e.g. vascular smooth muscle, cardiac cells, and pancreas) are well-established for characteristics like vasodilatation, myocardial protection against ischemia, and insulin secretion. The aim of this review is to get insight into the novel roles of K(ATP) channels in Parkinson's disease (PD), with consideration of the specificities K(ATP) channels in the central nervous system (CNS), such as the control of neuronal excitability, action potential, mitochondrial function and neurotransmitter release.
