Effect of resuscitation after selective cerebral ultraprofound hypothermia on expressions of nerve growth factor and glial cell line-derived neurotrophic factor in the brain of monkey.
- Author:
Xue-Cai HUANG
1
;
Wei XU
;
Ji-Yao JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain; metabolism; Cell Survival; physiology; Cerebrovascular Circulation; physiology; Cerebrovascular Disorders; metabolism; physiopathology; Cytoprotection; physiology; Glial Cell Line-Derived Neurotrophic Factor; metabolism; Hypothermia, Induced; Hypoxia-Ischemia, Brain; metabolism; physiopathology; prevention & control; Macaca mulatta; Nerve Growth Factor; metabolism; Neurons; metabolism; Recovery of Function; physiology; Reperfusion Injury; metabolism; physiopathology; prevention & control; Resuscitation; Up-Regulation; physiology
- From: Neuroscience Bulletin 2008;24(3):150-154
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the expression of nerve growth factor (NGF) and glial cell line-derived neurotrophic factor (GDNF) in monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion.
METHODSThe monkeys were immediately removed brain after death in operation of group A (identical temperature perfusion group) and group B (ultraprofound hypothermia perfusion group). Immunohistochemical technique was used to determine frontal cellular expression of NGF and GDNF. Statistics were analyzed by ANOVA analyses with significance level at P < 0.05.
RESULTSThe expressions of NGF and GDNF in the group B were significantly higher than those in the group A (P < 0.05).
CONCLUSIONNGF and GDNF increased significantly in the monkeys of resuscitation after selective cerebral ultraprofound hypothermia and blood flow occlusion. It may be a protective mechanism for neuron survival and neural function recovery.
