90d Exposure to Nonylphenol has Adverse Effects on the Spermatogenesis and Sperm Maturation of Adult Male Rats.

Wei Chen LU; Ai Qing Wang; Xiao Ling Chen; Guo Yang; Yao Lin; Yi Ou Chen; Cheng Jiao Hong; Hai Lin Tian

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90d Exposure to Nonylphenol has Adverse Effects on the Spermatogenesis and Sperm Maturation of Adult Male Rats.

Author: Wei Chen LU ^{1
,

2} ; Ai Qing WANG ³ ; Xiao Ling CHEN ¹ ; Guo YANG ⁴ ; Yao LIN ⁴ ; Yi Ou CHEN ⁴ ; Cheng Jiao HONG ³ ; Hai Lin TIAN ⁴
Author Information

1. Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China
2. KunShan Health Inspection Station, 458 Tongfeng Road, Kunshan 215301, Jiangsu, China.
3. Experimental Center of Medical College, Soochow University, Suzhou 215123, Jiangsu, China.
4. Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China.
Publication Type:Letter
MeSH: Administration, Oral; Animals; Apoptosis; drug effects; Dose-Response Relationship, Drug; Epididymis; drug effects; metabolism; pathology; Male; Oxidative Stress; drug effects; Phenols; adverse effects; Rats, Sprague-Dawley; Sperm Motility; drug effects; Spermatogenesis; drug effects; Spermatozoa; drug effects; metabolism; pathology; Testis; drug effects; metabolism; pathology; Testosterone; blood
From: Biomedical and Environmental Sciences 2014;27(11):907-911
CountryChina
Language:English
Abstract: This study was conducted to elucidate the reproductive effect of NP on testis, epididymis and epididymal sperm in vivo. Adult male Sprague-Dawley rats were gavaged with NP at 0, 40, 100, or 250 mg/kg body weight (bw) on alternate days for 90 d. The results showed that oral administration of NP may damage the structure and function of testis, induce apoptosis and oxidative stress in epididymis or even have cytotoxic effects on epididymal sperm.