Gene-gene interaction of GJB2, SOD2, and CAT on occupational noise-induced hearing loss in Chinese Han population.

Sheng Li Wang; Lu Gang YU; Ren Ping Liu; Wan Zhan Zhu; Wei Min Gao; Li Ping Xue; Xu Jiang; Ya Han Zhang; Ding YI; Dong Chen; Yong Hong Zhang

Return

Gene-gene interaction of GJB2, SOD2, and CAT on occupational noise-induced hearing loss in Chinese Han population.

Author: Sheng Li WANG ^{1
,

2} ; Lu Gang YU ³ ; Ren Ping LIU ³ ; Wan Zhan ZHU ³ ; Wei Min GAO ³ ; Li Ping XUE ³ ; Xu JIANG ³ ; Ya Han ZHANG ³ ; Ding YI ³ ; Dong CHEN ⁴ ; Yong Hong ZHANG ⁴
Author Information

1. Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China
2. Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China.
3. Suzhou Industrial Park Centers for Disease Control and Prevention (Institute of Health Inspection and Supervision), Suzhou 215021, Jiangsu, China.
4. Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
Publication Type:Letter
MeSH: Asian Continental Ancestry Group; genetics; Case-Control Studies; Catalase; genetics; China; Connexin 26; Connexins; genetics; Genetic Predisposition to Disease; Hearing Loss, Noise-Induced; genetics; Humans; Male; Superoxide Dismutase; genetics
From: Biomedical and Environmental Sciences 2014;27(12):965-968
CountryChina
Language:English
Abstract: The effects of genetic factors on the noise-induced hearing loss (NIHL) are still unclear. In the present study, eight single-nucleotide polymorphisms (SNPs) included rs1227049 and rs3802711 (CDH23), rs1695 (GSTP1), rs137852540 (GJB2), rs2289274 (PMCA2), rs4880 (SOD2), rs7943316, and rs769214 within CAT that might associated with NIHL were further validated in Chinese workers. The results showed that the carriers of the T allele (AT+TT) of rs7943316 and A allele (GA+AA) of rs769214, were significantly associated with an increased risk of NIHL compared to those with AA genotype (P<0.05) and GG genotype (P<0.05). Moreover, a significant three-locus model (P=0.0107) involving rs2016520, rs9794, and rs1805192 were observed that might associated with NIHL, with 53.95% of testing accuracy. Thus, our present study provided the evidence that GJB2, SOD2, and CAT genes might account for the NIHL development in independently and/or in an interactive manner.