Genetic and environmental effects on the bone development of the hand and wrist in Chinese young twins.
- Author:
Li Yan DONG
1
,
2
;
Ji Bin TAN
3
;
Jing Lan ZHAO
4
;
Fa Chun JIANG
5
;
Xiao Cao TIAN
5
;
Feng NING
5
;
Shao Jie WANG
5
;
Dong Feng ZHANG
6
;
Zeng Chang PANG
1
;
Zhong Tang ZHAO
7
Author Information
- Publication Type:Letter
- MeSH: Adolescent; Bone Development; genetics; Child; Child, Preschool; China; Environmental Exposure; Hand Bones; growth & development; Humans; Twins, Dizygotic; Twins, Monozygotic; Wrist; growth & development
- From: Biomedical and Environmental Sciences 2015;28(3):235-238
- CountryChina
- Language:English
- Abstract: We assessed genetic and environmental effects on bone development of the hand and wrist, and on key anthropometric measures in Chinese young twins. In total, 139 monozygotic and 95 dizygotic twin pairs aged from 5 to 18 years were recruited. The twin correlations of total hand and wrist scores for monozygotic (MZ) and dizygotic (DZ) twins were 0.71 and 0.36, respectively. Bivariate model analysis showed moderate genetic correlations only for total skeletal maturity vs. weight and total skeletal maturity vs. waist circumference (r, 0.51 and 0.46, respectively). Our findings demonstrated that genetic factors played important roles in bone development of the hand and wrist in Chinese young twins, and that these genetic effects might be distinct from those influencing anthropometric measures.