Neurobehavioral Assessment of Rats Exposed to Yttrium Nitrate during Development.

Chen Xi LI; Chuan MA; Hai Qin FANG; Yuan ZHI; Zhou YU; Hai Bin XU; Xu Dong JIA

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Neurobehavioral Assessment of Rats Exposed to Yttrium Nitrate during Development.

Author: Chen Xi LI ^{1
,

2} ; Chuan MA ³ ; Hai Qin FANG ³ ; Yuan ZHI ³ ; Zhou YU ³ ; Hai Bin XU ³ ; Xu Dong JIA ³
Author Information

1. National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China
2. Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
3. Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China.
Publication Type:Journal Article
Keywords: Developmental neurotoxicity; Neurobehavior; Rare earth elements; Yttrium
MeSH: Animals; Dose-Response Relationship, Drug; Environmental Pollutants; toxicity; Female; Food Safety; Male; Maze Learning; drug effects; Motor Activity; drug effects; Pain Measurement; drug effects; Pregnancy; Prenatal Exposure Delayed Effects; chemically induced; physiopathology; Random Allocation; Rats; Rats, Sprague-Dawley; Risk Assessment; Rotarod Performance Test; Yttrium; toxicity
From: Biomedical and Environmental Sciences 2015;28(4):281-290
CountryChina
Language:English
Abstract:
OBJECTIVEThe aim of this study was to assess the effects of yttrium nitrate on neurobehavioral development in Sprague-Dawley rats.
METHODSDams were orally exposed to 0, 5, 15, or 45 mg/kg daily of yttrium nitrate from gestation day (GD) 6 to postnatal day (PND) 21. Body weight and food consumption were monitored weekly. Neurobehavior was assessed by developmental landmarks and reflexes, motor activity, hot plate, Rota-rod and cognitive tests. Additionally, brain weights were measured on PND 21 and 70.
RESULTSNo significant difference was noted among all groups for maternal body weight and food consumption. All yttrium-exposed offspring showed an increase in body weight on PND 21; however, no significant difference in body weight for exposed pups versus controls was observed 2 weeks or more after the yttrium solution was discontinued. The groups given 5 mg/kg daily decreased significantly in the duration of female forelime grip strength and ambulation on PND 13. There was no significant difference between yttrium-exposed offspring and controls with respect to other behavioral ontogeny parameters and postnatal behavioral test results.
CONCLUSIONExposure of rats to yttrium nitrate in concentrations up to 45 mg/kg daily had no adverse effects on their neurobehavioral development.