Inhibiting Smooth Muscle Cell Proliferation via Immobilization of Heparin/Fibronectin Complexes on Titanium Surfaces.
- Author:
Gui Cai LI
1
,
2
;
Qi Fei XU
3
;
Ping YANG
4
Author Information
- Publication Type:Letter
- MeSH: Biocompatible Materials; Cell Proliferation; drug effects; physiology; Cells, Cultured; Fibronectins; chemistry; pharmacology; Heparin; chemistry; pharmacology; Humans; Immobilized Proteins; chemistry; Muscle, Smooth, Vascular; cytology; Myocytes, Smooth Muscle; drug effects; physiology; Surface Properties; Titanium; chemistry; Umbilical Arteries
- From: Biomedical and Environmental Sciences 2015;28(5):378-382
- CountryChina
- Language:English
- Abstract: The aim of this study was to investigate the inhibitory effect of heparin/fibronectin (Hep/Fn) complexes on neointimal hyperplasia following endovascular intervention. Hep/Fn complexes were immobilized onto titanium (Ti) surfaces, with subsequent X-ray photoelectron spectroscopy (XPS), Toluidine Blue O (TBO) and immunohistochemistry methods were used to characterize surface properties. Smooth muscle cell (SMC) cultures were used to evaluate the effect of Hep/Fn complexes on SMC proliferation. Results showed that Hep/Fn complexes successfully immobilized onto Ti surfaces and resulted in an inhibition of SMC proliferation. This study suggests that Hep/Fn surface-immobilized biomaterials develop as a new generation of biomaterials to prevent neointimal hyperplasia, particularly for use in cardiovascular implants.
