Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese: a Case-control Study.

Hai Fei You; Jing Zhi Zhao; Yu Jia Zhai; Lei Yin; Chao Pang; Xin Ping Luo; Ming Zhang; Jin Jin Wang; Lin Lin LI; Yan Wang; Qian Wang; Bing Yuan Wang; Yong Cheng Ren; Dong Sheng HU

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Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese: a Case-control Study.

Author: Hai Fei YOU ^{1
,

2} ; Jing Zhi ZHAO ³ ; Yu Jia ZHAI ⁴ ; Lei YIN ³ ; Chao PANG ³ ; Xin Ping LUO ⁵ ; Ming ZHANG ⁵ ; Jin Jin WANG ⁶ ; Lin Lin LI ⁷ ; Yan WANG ⁷ ; Qian WANG ⁷ ; Bing Yuan WANG ⁷ ; Yong Cheng REN ⁷ ; Dong Sheng HU ⁵
Author Information

1. Department of Blood Transfusion, Xijing Hospital, The Fourth Military Medical University, Xi'an 710023, Shannxi, China
2. Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
3. Military Hospital of Henan Province, Zhengzhou 450003, Henan, China.
4. Department of Public Health Surveillance & Advisory, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China.
5. Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, China.
6. Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan, China.
7. Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
Publication Type:Journal Article
Keywords: Gene polymorphism; Haplotype; Low-density lipoprotein receptor-related protein 5; Metabolic characteristics; Type 2 diabetes mellitus
MeSH: Asian Continental Ancestry Group; genetics; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2; blood; genetics; Female; Haplotypes; Humans; Logistic Models; Low Density Lipoprotein Receptor-Related Protein-5; genetics; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Rural Population; Triglycerides; blood
From: Biomedical and Environmental Sciences 2015;28(7):510-517
CountryChina
Language:English
Abstract:
OBJECTIVETo investigate the association between low-density lipoprotein receptor-related protein 5 (LRP5) variants (rs12363572 and rs4930588) and type 2 diabetes mellitus (T2DM) in Han Chinese.
METHODSA total of 1842 T2DM cases (507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms (SNPs). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to describe the strength of the association by logistic regression.
RESULTSIn the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2DM, even after adjusting for relevant covariates. When stratified by body mass index (BMI), the two SNPs were also not associated with T2DM. Among the 3 common haplotypes, only haplotype TT was associated with reduced risk of T2DM (OR 0.820, 95% CI 0.732-0.919). In addition, rs12363572 was associated with BMI (P<0.001) and rs4930588 was associated with triglyceride levels (P=0.043) in 507 newly diagnosed T2DM cases but not in healthy controls.
CONCLUSIONNo LRP5 variant was found to be associated with T2DM in Han Chinese, but haplotype TT was found to be associated with T2DM.