A Case-control Study of Environmental Risk Factors for Nonsyndromic Cleft of the Lip and/or Palate in Xuzhou, China.
- Author:
Li Fang XU
1
;
Xiao Long ZHOU
1
;
Qi WANG
1
;
Ji Long ZHOU
1
;
Ya Peng LIU
1
;
Qiang JU
1
;
Hui WANG
1
;
Jin Peng ZHANG
1
;
Qing Rong WU
2
;
Yi Qun LI
2
;
Yu Juan XIA
2
;
Xiu PENG
2
;
Mei Rong ZHANG
1
;
Hong Min YU
1
;
Li Chun XU
1
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; China; epidemiology; Cleft Lip; epidemiology; etiology; prevention & control; Cleft Palate; epidemiology; etiology; prevention & control; Environmental Pollutants; toxicity; Female; Folic Acid; administration & dosage; therapeutic use; Humans; Infant, Newborn; Logistic Models; Maternal Exposure; adverse effects; Pregnancy; Risk Factors; Socioeconomic Factors; Surveys and Questionnaires
- From: Biomedical and Environmental Sciences 2015;28(7):535-538
- CountryChina
- Language:English
- Abstract: In this study, we sought to determine the association between environmental factors and nonsyndromic cleft of the lip and/or palate (NSCLP) to understand the etiology of the disease. A total of 200 NSCLP cases and 327 controls were recruited at the Maternal and Child Health Hospital of Xuzhou City. We conducted face-to-face interviews with the mothers of both cases and controls. The factors increasing the risk of NSCLP were a positive family history [odds ratio (OR)=56.74], pesticide exposure (OR=8.90), and indoor decoration pollution (OR=4.32). On the other hand, the factors decreasing the risk of NSCLP were a high education level (OR=0.22) and supplementation of folic acid (OR=0.23) and multivitamins (OR=0.16). Positive family history, pesticide exposure, and indoor decoration pollution are associated with the risk of NSCLP. In contrast, high education level and folic acid and multivitamin supplementation are protective factors against NSCLP.
