The Epidemiological Characteristics of Beijing Lineage Mycobacterium tuberculosis from a National Referral Center in China.
- Author:
Xiao Ying LI
1
;
Ying LI
2
;
Yao ZHANG
3
;
Wan Li KANG
4
;
Li Ping ZHAO
5
;
Peng Ju DING
6
;
Wen Tao DAI
7
;
Hai Rong HUANG
5
;
Yan Feng HUANG
8
;
Wei Min LI
5
;
Author Information
- Publication Type:Journal Article
- MeSH: China; epidemiology; DNA, Bacterial; genetics; Genome, Bacterial; Hospitals, Chronic Disease; Humans; Molecular Epidemiology; Mycobacterium tuberculosis; classification; genetics; isolation & purification; Phylogeny; Phylogeography; Polymorphism, Single Nucleotide; Tuberculosis; epidemiology; microbiology
- From: Biomedical and Environmental Sciences 2015;28(7):539-543
- CountryChina
- Language:English
- Abstract: Our study was to investigate the epidemiological characteristics of M.tuberculosis from a national tuberculosis referral center in China. All strains isolated from TB patients, were genotyped by the RD105 deletion, 8 and 51 SNP loci and VNTR. The high differentiation SNPs of modern Beijing strains were analyzed for protein function and structure. 413 M. tuberculosis were included. Of 379 Beijing lineage M. tuberculosis, 'modern' and 'ancient' strains respectively represented 85.5% (324/379) and 14.5% (55/379). Rv2494 (V48A) and Rv0245 (S103F) were confirmed as high differentiation SNPs associated with modern strains. In a word, Modern Beijing lineage M.tuberculosis was dominant and the structural models suggested that modern sub-lineage may more easily survive in 'extreme' host condition.