Effect of weight loss induced by laparoscopic adjustable gastric banding on immunity of morbid obesity.
- Author:
Ming-gen HU
1
;
Cheng-zhu ZHENG
;
Chong-wei KE
;
Kai YIN
;
Ji-hui LI
;
Bin HU
;
Yue-feng WU
;
Ping CAO
;
Da-jin ZOU
;
Jun ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Female; Follow-Up Studies; Gastroplasty; methods; Humans; Laparoscopy; Male; Obesity, Morbid; immunology; surgery; Weight Loss
- From: Chinese Journal of Surgery 2005;43(5):309-312
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the immunity of morbid obesity (MO) before and after laparoscopic adjustable gastric banding (LAGB).
METHODS15 cases, with a mean body mass index (BMI) of 35.8 kg/m(2), were treated by LAGB from Jun. 2003 to Oct. 2003 in our department. Patients' immune parameters were determined preoperatively and 1, 3 and 6 months postoperatively. 15 cases with a normal BMI (23.6 kg/m(2)) were set as controls.
RESULTSBefore surgery, the MO had a significant lower level of CD(4)(+), CD(4)(+)/CD(8)(+) and a higher level of serum interleukin-2 (IL-2), Interleukin-6 (IL-6) than the controls (P < 0.01). There was a significant reduction of weight and BMI 6 months postoperatively (P < 0.01). At the same time, CD(4)(+) increased and serum IL-2 decreased significantly. But CD(4)(+)/CD(8)(+)and serum IL-2, IL-6 were still abnormal compare to the controls.
CONCLUSIONSMO may combined with an abnormal immunity. But after enough weight loss induced by LAGB, it can be partly reversed.
