Expression of SSX2 gene in human urologic neoplasms.
- Author:
Peng DU
1
;
Li-zhang YU
;
Ming MA
;
Lin GENG
;
Xiao-song WANG
;
Dian-qi XIN
;
Yan-qun NA
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell; genetics; pathology; Carcinoma, Transitional Cell; genetics; pathology; Female; Gene Expression; Humans; Kidney Neoplasms; genetics; pathology; Male; Middle Aged; Neoplasm Proteins; genetics; RNA, Messenger; genetics; Repressor Proteins; genetics; Reverse Transcriptase Polymerase Chain Reaction; Urethral Neoplasms; genetics; pathology
- From: Chinese Journal of Surgery 2005;43(6):379-381
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of SSX(2)gene in human renal cell carcinoma and urinary transitional cell carcinoma.
METHODSReverse-transcription polymerase chain reaction (RT-PCR) was used for detecting SSX(2) gene in the specimens from renal cell carcinoma (n = 26), urinary transitional cell carcinoma (n = 27) and in 15 specimens taken from the tumor surrounding tissues.
RESULTSPositive expression of SSX(2) gene at mRNA was detected in 69% renal cell carcinomas (18/26), in 81% urinary transitional cell carcinomas (22/27). The mRNA of SSX(2) was not detected in the 15 specimens from tumor surrounding tissues.
CONCLUSIONThe SSX(2) gene is highly expressed in human renal cell carcinoma and urinary transitional cell carcinoma.
