Clinical significance and relationship of expression of matrix metalloproteinase-2 mRNA with breast cancer metastasis.
- Author:
Chun-Hua XIAO
1
;
Yu-Mei FENG
;
Xiao-Qing LI
;
Xi-Shan HAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Breast Neoplasms; enzymology; pathology; Female; Humans; Lymph Nodes; pathology; Matrix Metalloproteinase 2; biosynthesis; genetics; Middle Aged; Neoplasm Metastasis; RNA, Messenger; genetics; Receptors, Estrogen; biosynthesis; Receptors, Progesterone; biosynthesis; Reverse Transcriptase Polymerase Chain Reaction
- From: Chinese Journal of Surgery 2005;43(9):599-604
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo discuss the clinical significance of matrix metalloproteinase-2 (MMP-2) mRNA and the relationship of MMP-2 mRNA expression with breast cancer metastasis.
METHODDetect MMP-2 mRNA expression of 30 breast cancer, metastatic lymphnode and 116 clinical breast cancer samples by flurence-quantitative RT-PCR and analysis the relativity of MMP-2 mRNA expression with clinical, pathology factors.
RESULTSMMP-2 mRNA expression in 30 metastatic lymphnode is lower than in primary breast cancer (t = -3.293, P < 0.05). The mRNA expression of MMP-2 in tumor > 2 cm is lower than in tumor
CONCLUSIONSMMP-2 mRNA expression is up-regulated in early clinic stage, lymphnode metastatic early stage, and down regulated with tumor progressing. MMP-2 mRNA expression is related with the metastasis of breast cancer.
