The prognostic value of human neuroendocrine clone on colorectal carcinoma.
- Author:
Xiao-dong YANG
1
;
Shan WANG
;
Hui-yan MENG
;
Ying-jiang YE
;
You-zhi YU
;
Ke-wei JIANG
;
Shen YANG
;
Jun QU
;
Wei-gang FANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Carcinoma, Neuroendocrine; metabolism; mortality; pathology; Chromogranins; biosynthesis; Colorectal Neoplasms; metabolism; mortality; pathology; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Prognosis; Retrospective Studies; Survival Rate; Synapsins; biosynthesis
- From: Chinese Journal of Surgery 2005;43(11):706-709
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo demonstrate the prognostic value of neuroendocrine clone on colorectal carcinoma.
METHODSThe immunochemistry methods were used to investigate the percent of neuroendocrine carcinoma in 73 human colorectal carcinoma. Retrospective analysis and follow-up were carried out in all patients.
RESULTSIn all 73 cases of colorectal carcinoma, the total percentage of neuroendocrine carcinoma was 17.8%. Neuroendocrine carcinoma included 11 synapse positive, 6 chromogranin positive and 4 both positive. The major factors related to the prevalence of neuroendocrine carcinoma were sex, age, tumor location and Dukes' stage. And the 1-year survival rate of the patients who suffered from neuroendocrine carcinoma is obviously lower than that of other colorectal carcinoma.
CONCLUSIONSThe neuroendocrine carcinoma is a special kind of human colorectal carcinoma, and neuroendocrine clone may be a new marker of the malignant potency. The neuroendocrine clone has its prognostic value and may be a novel therapeutic target.
