The effect of basic fibroblast growth factor on the gene expression of decorin by periodontal ligament fibroblasts in culture.
- Author:
Si-cong WANG
1
;
Chong-tao LIN
;
Dai-bang NIE
;
Hong-sheng OUYANG
Author Information
- Publication Type:Journal Article
- MeSH: Decorin; Fibroblast Growth Factor 2; Fibroblasts; Humans; Periodontal Ligament; RNA, Messenger; Regeneration
- From: West China Journal of Stomatology 2008;26(4):352-354
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of basic fibroblast growth factor (bFGF) on the gene expression of decorin by periodontal ligament fibroblasts (PLFs) in culture, and discuss the effect of bFGF in periodontal regeneration.
METHODSHuman PLFs were cultured and stimulated by exogenous bFGF. Gene expression of decorin was assessed by semi-quantitive RT-PCR.
RESULTSThe mRNA expression of decorin was suppressed by bFGF and the effect was dose-dependent. When the dose of bFGF increased, the inhibitive effect decreased.
CONCLUSIONDecorin has many biological effects. The inhibitive effect may be one of important factors which participate in the healing process of periodontitis, and provide partly theoretical basis of bFGF in periodontal regeneration.
