Expression and significance of vascular cell adhesion molecule-1 in human oral squamous cell carcinoma.
- Author:
Le-gang SUN
1
;
Fang WANG
;
Ling LIU
;
Yu-feng SONG
;
You-cheng YANG
;
Li-fang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Squamous Cell; Humans; In Situ Hybridization; Lymphatic Metastasis; Middle Aged; Mouth Mucosa; Mouth Neoplasms; RNA, Messenger; Vascular Cell Adhesion Molecule-1
- From: West China Journal of Stomatology 2008;26(6):591-594
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression and the location of vascular cell adhesion molecule-1 (VCAM-1) gene and its clinical significance in human oral squamous cell carcinoma (OSCC).
METHODSIn situ hybridization, PV-9000 polymer detection system for immunohistochemical staining was used to detect the expression and the location of VCAM-1 mRNA and VCAM-1 protein in 48 cases of OSCC and 10 cases of normal controls. Statistical analysis was performed using chi-square test in SPSS 13.0.
RESULTSVCAM-1 protein was mainly expressed in tumor cell cytoplasm and membrane, VCAM-1 mRNA was mainly expressed in tumor cell cytoplasm. The expression rate of VCAM-1 mRNA and VCAM-1 protein was significantly higher in OSCC than that in normal oral mucosa (P<0.01). The expression of VCAM-1 mRNA was positively correlated with that of VCAM-1 protein (P<0.01). In the clinicopathologic factors, lymph node metastasis and depth of infiltration were closely correlated with VCAM-1 expression (P<0.01). The expression of VCAM-1 was significantly higher in tumor with lymph node metastasis than in tumor without lymph node metastasis (P<0.01).
CONCLUSIONOverexpression of VCAM-1 gene in OSCC may play a potential role in the development of OSCC. The overexpression of VCAM-1 gene in OSCC may be related to the tumor infiltration and metastasis.