Intake of volatile N-nitrosamines and their ability to exogenously synthesize in the diet of inhabitants from high-risk area of esophageal cancer in southern China.
- Author:
Kun LIN
1
;
Zhong-Ying SHEN
;
Shih-Hsin LU
;
Yong-Ning WU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; China; epidemiology; Diet; Esophageal Neoplasms; epidemiology; etiology; Female; Humans; Male; Middle Aged; Nitrosamines; administration & dosage; adverse effects; Risk Factors; Volatilization
- From: Biomedical and Environmental Sciences 2002;15(4):277-282
- CountryChina
- Language:English
-
Abstract:
OBJECTIVENan'ao County in Guandong Province is a high-risk area of esophageal cancer in Southern China. Of the suspected etiological factors in the environment, N-nitrosamines and their precursors have received the greatest attention.
METHODSSixty samples of the diet ingested by the inhabitants were collected and detected for volatile N-nitrosamines and their precursors. Five N-nitrosamines detected by Gas Chromatography-Thermal Energy Analyzer were N-nitrosodimethylamine, N-nitrosodiethylamine, N-nitrosopyrrolidine, N-nitrosopiperidine and N-nitrosomethyl-benzylamine.
RESULTSThe average content of 5 volatile N-nitrosamines in the diet was 312.0 micrograms/kg (median). The daily intake of the nitrosamines was 286.5 micrograms/head/day. Only the ability to exogenously synthesize N-nitrosopiperidine was powerful among 5 volatile N-nitrosamines. By a computerized stepwise regression analysis and curve fitting, we studied the correlation among the nitrosamines, the precursors and the major food items in the samples.
CONCLUSIONIt demonstrated that a relatively high content of volatile N-nitrosamines was present in the diet collected in the area.
