A Comparative Study of the Toxicity Between carboplatin and Cisplatin in VBP Combination Chemotherapy.
- Author:
Pan Young KIM
;
Hee Sung SEO
;
Jung Ok SHIN
;
Kyung Taeck JANG
;
Dong Han BAE
- Publication Type:Comparative Study ; Original Article
- Keywords:
Toxicity;
Cisplatin;
Carboplatin
- MeSH:
Agranulocytosis;
Carboplatin*;
Carcinoma, Squamous Cell;
Cisplatin*;
Drug Therapy, Combination*;
Head and Neck Neoplasms;
Humans;
Lung;
Ovarian Neoplasms;
Platinum;
Thrombocytopenia;
Uterine Cervical Neoplasms
- From:Korean Journal of Gynecologic Oncology and Colposcopy
1996;7(3):189-198
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Cisplatin has been widely used as chemotherapeutic agent for the treatment of cervical cancer, ovarian cancer, head and neck cancer and squamous cell carcinoma of lung. But cisplatin is highly toxic with nephrotoxicity, gastrointestinal toxicity, myelosuppression and neurotoxicity. The second generation drug of platinum compound, carboplatin was developed in 1980s to reduce side effects. Carboplatin has low nephrotoxicity but its major toxic effect is thrombocytopenia, In this study, the side effects of cisplatin and carboplatin were evaluated on 37 patients of cervical cancer in 169 chemotherpy cycles who were recieved combined VBP chemotherpeutic regimen consisting of cisplatin or carboplatin. Nephrotoxicity of grade 2 or over were 16% in cisplatin group and 1% in carboplatin group. Granulocytopenia of grade 2 or over were 34% in cisplatin group and 10% in carboplatin group. Thrombocytopenia of grade 2 or over were 7% in cisplatin group and 21% in carboplatin group. Gastrointestinal toxicity of grade 2 or over were 11% in cisplatin group and 0% in carboplatin group. This clinical study demonstrated that cisplatin has more toxic effects than carboplatin except thrombocytopenia.
