Study on relationship between Arg778Leu/Gln gene mutation spot in ATP7B and TCM syndrome type in Chinese patients with Wilson disease.
- Author:
Bin YANG
1
;
Ji-yuan HU
;
Ming-fan HONG
Author Information
- Publication Type:Journal Article
- MeSH: Adenosine Triphosphatases; genetics; Adolescent; Arginine; genetics; Asian Continental Ancestry Group; Cation Transport Proteins; genetics; Child; Copper-transporting ATPases; Diagnosis, Differential; Exons; Female; Hepatolenticular Degeneration; diagnosis; genetics; Humans; Leucine; genetics; Male; Medicine, Chinese Traditional; Phenotype; Point Mutation
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(4):280-282
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between Arg778Leu/Gln gene mutation spot in ATP7B and TCM Syndrome type in Chinese patients with Wilson disease (WD).
METHODSExon 8 of ATP7B of 90 WD patients and 30 healthy controls were amplified by PCR and analysed by restriction enzyme Msp I, the TCM Syndrome type of the patients was differentiated at the same time.
RESULTSIn the 90 WD patients, 34 with Arg778Leu/Gln of exon 8 were detected, among them 20 cases belonged to the TCM Syndrome type of endogenous Liver-Wind agitation.
CONCLUSIONOnset age of WD patients with Arg778Leu/Gln mutation is later than that without this mutation. Arg778Leu/Gln mutation might be related to the TCM Syndrome type of endogenous Liver-Wind agitation.
