Clinical immunological study on prevention and treatment of chronic pyelonephritis with yishenkang granule.
- Author:
Jian-shi SUN
1
;
Yan-qiu XU
;
Hong MENG
Author Information
- Publication Type:Clinical Trial
- MeSH: Adult; Chronic Disease; Complement C3; metabolism; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Immunoglobulin G; blood; Interleukin-2; blood; Male; Middle Aged; Pyelonephritis; drug therapy; immunology; prevention & control; T-Lymphocyte Subsets; drug effects
- From: Chinese Journal of Integrated Traditional and Western Medicine 2002;22(5):337-340
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between chronic pyelonephritis (CPN) and immune function, and the therapeutic mechanism of Yishenkang granule (YSKG).
METHODSOne hundred and twenty patients of CPN were divided into 3 groups randomly, the YSKG group (treated with YSKG), the control A group (treated with Sanjin tablet) and the control B group (treated with western medicine). Serum levels of immunoglobulin (Ig), complement 3 (C3), interleukin-2 (IL-2), peripheral T-lymphocyte subsets, and urinary secretory immunoglobulin A (sIgA) were determined before and after treatment with monoclonal antibody assay, agar diffusion method, radioimmunoassay (RIA), and radioimmuno-equilibrium method, and compared with normal control.
RESULTSThere were disorders of T-lymphocyte subsets in CPN, lowering of serum Ig, C3 and urinary sIgA, and increase of blood IL-2 (P < 0.05 or P < 0.01). These abnormalities could be normalized after YSKG treatment.
CONCLUSIONFunctional disorders of cellular and humoral immunity exist in CPN patients of chronic stage, YSKG could correct the immune functional disorder, control the recurrence of CPN effectively and alleviate the immunopathological damage.
